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Non-Allergic Rhinitis (Vasomotor)

Non-Allergic Rhinitis (Vasomotor)

Non-allergic rhinitis is a chronic condition that can occur at any age but is more common in adults. The most common symptoms are nasal congestion, post-nasal drainage, and headache, although runny nose, sneezing and itching of the nose may occur in some non-allergic individuals. Many non-allergic patients have recurrent sinusitis and middle ear infections or middle ear fluid collection.

Initial evaluation requires that surgical conditions (growths in the nose, crooked nasal septum, etc.) and general medical conditions (thyroid disease, pregnancy, etc.) are not responsible for the chronic symptoms. We recommend that ever patient have a family practitioner, internist, or pediatrician to follow them for their general medical care. If the history and physical examination are not positive for surgical or general medical problems, the patient most likely has the most common nasal problem of non-allergic or allergic nasal disease.

Non-allergic rhinitis is a very difficult topic to fully understand. The actual defect resulting in the symptoms commonly found is not known. We do know that the difficulty arises in the inability to correctly change the size of blood vessels and the quantity of mucus produced by mucus glands in the nose. Under normal circumstances the nose warms or cools the air entering the nose to 98 degrees F., increases the humidity to at least 80%, and filters unwanted substances resulting in relatively clean air at 98 degrees F. and 80% humidity entering the lungs regardless of current environmental conditions. These changes occur almost instantly with each breath. The non-allergic individual has lost the ability to make the necessary changes either from an ineffective blood vessel and mucus gland controlling mechanism, temperature and humidity sensing mechanism, or both. The end result is inappropriate blood vessel size and/or excess mucus production which can result in nasal congestion, post-nasal drainage, and headaches.

Many individuals with non-allergic nasal disease will have a significant amount of irritation, inflammation, and hyperreactivity in the nose contributing to the persistent, chronic nature of the disease.

Nasal allergy on the other hand usually presents with runny nose, sneezing, and itching but some patients can also have nasal congestion, post-nasal drainage, and headaches. With nasal allergy we usually see definite problems at certain seasons of the year or a correlation with exposures to dust, animal dander, mold or mildew exposures and in some patients’ extreme reactions to certain foods. Allergy symptoms also involving the eyes usually are redness, itching and watering of the eyes.

It is possible for an individual to have problems with both non-allergic rhinitis and allergic rhinitis, and this makes the problems at times more difficult to clearly diagnose and treat.

Several tests can be used to differentiate non-allergic rhinitis from allergic rhinitis. Skin testing, as one might expect, displays positivity in patients with allergic rhinitis, whereas a negative skin test will be obtained in patients with non-allergic rhinitis. In addition, the blood IgE levels and eosinophils (the allergy cell) are elevated in patients with allergic rhinitis but not in non-allergic rhinitis.

Non-allergic rhinitis often is triggered by drafts, temperature changes (especially cold air), by scented cosmetics (both men’s and women’s cosmetics), by cigarette and tobacco smoke, as well as fireplace smoke, scented or perfumed soaps. Many types of aerosol sprays, even scented deodorants can cause problems. Paint fumes, insecticides, bug sprays,
varnishes, and even the odor from new clothing, carpeting or furniture can cause problems. Kerosene, lighter fluids, oil and gas fumes can cause problems. House dust may act as an irritant, and should be avoided.

Do not overuse over-the-counter decongestant sprays or nose drops because these can cause “rebound” nasal congestion. All nasal decongestant sprays should be discontinued following 3 days of continuous use. Medications will be prescribed to help with this problem. A good part of the treatment is avoiding known problems and exposures, and working by trial and error to find medications that work best in your case. Medications that may be tried include: Astelin© nasal spray, decongestants, decongestant-antihistamine combinations, intranasal steroid sprays, and possibly an atropine-derivative nasal spray (Atrovent©).

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Biologics for the Management of Severe Asthma

For many patients with asthma, their asthma is controlled by identifying and avoiding triggers, taking a daily inhaled or oral controller medication, and using a quick-relief inhaler when symptoms develop. For some patients though, these medications are not enough to control their asthma. Recently, several new medications, known collectively as “biologics,” have been approved for the treatment of moderate-to-severe asthma. Biologics are unique in that they target a specific antibody, molecule, or cell involved in asthma. Because of this, they are known as “precision” or “personalized” therapy.

What is a biologic?
A biologic is a medication made from the cells of a living organism, such as bacteria or mice, that is then modified to target specific molecules in humans. For asthma, the targets are antibodies, inflammatory molecules, or cell receptors. By targeting these molecules, biologics work to disrupt the pathways that lead to inflammation that causes asthma symptoms.  

When would you need a biologic?
A biologic is used for patients who continue to have symptoms despite use of standard daily controller medications. Symptoms of poorly controlled asthma include frequent coughing, wheezing, or shortness of breath; waking up at night with difficulty breathing; requiring a fast-acting reliever medication, such as albuterol, several times a day or week; and recurrent hospital admissions, emergency room visits, or need for oral steroids for exacerbations. Before prescribing a biologic, your doctor should make sure you are taking your other controller medications as instructed, avoiding any potential triggers for your asthma, and treat any other associated medical conditions that could be making your asthma worse.  

What are the benefits of a biologic?
The primary benefit of biologics has been a decrease in the frequency of asthma exacerbations, including emergency room visits, hospitalizations, and need for oral steroids. Other benefits include reduced asthma symptoms, reduced dosage of other controller medication, and less missed school and work days. Biologics have been shown to improve quality of life for patients with asthma. Some biologics have been found to improve lung function in patients with severe asthma.  

What biologics are available for asthma?
Currently there are six approved biologics for asthma – omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab, and tezepelumab – with several others currently in development. Omalizumab targets allergy antibodies known as IgE. Mepolizumab, reslizumab, and benralizumab all target pathways that affect eosinophils, a cell involved in allergic inflammation. Dupilumab targets a receptor for two molecules that drive allergic inflammation.  Tezepelumab blocks a chemical thought to be important in the initiation and persistence of airway inflammation. Your doctor will obtain screening tests, such as blood work or environmental allergen skin prick testing, to help decide which biologic would be best to treat your asthma. Omalizumab is approved for patients as young as 6 years old, while all the other biologics except for reslizumab are approved for patients as young as 12 years old. Reslizumab is approved for adults 18 and over.

How are biologics administered?
Unlike other medications for asthma, most biologics are currently administered in a doctor’s office either as a subcutaneous injection or as an intravenous infusion when beginning treatment. With some biologics, your doctor may want to observe you in the office between 30 minutes and two hours after administration. Many biologics may eventually be administered at home. The frequency of administration of each of these biologics are different, ranging from every two weeks to every eight weeks.

What are the side effects of biologics?
Overall, studies have shown biologics to be very safe. For one of these medications, omalizumab, there has been a small risk of anaphylaxis. In this case, your doctor will likely prescribe an epinephrine autoinjector to have in case of a severe reaction. With mepolizumab, your doctor may ask if you are at risk for certain types of parasitic infections or ask about your varicella vaccination status prior to administering. Other common side effects include soreness at the injection site, headache, sore throat, and fatigue.

How long do I need to be on a biologic?
There are currently no set recommendations on how long a patient should be on a biologic.  Guidelines recommend trialing the medication for at least four months to see if it is helping improve your asthma. Your doctor will work with you to decide how long to keep you on a biologic if your asthma is under good control.

How much do biologics cost?
Compared to other controller medications for asthma, biologics are more expensive, costing upwards of thousands of dollars per year or more. Given the cost, you and your doctor should work together to see if they are the best medications for you. You should also check with your insurance company to make sure they are covered prior to starting.

Source: https://www.aaaai.org/tools-for-the-public/conditions-library/asthma/biologics-for-the-management-of-severe-asthma

The post Biologics for the Management of Severe Asthma appeared first on Oklahoma Allergy and Asthma Clinic.

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